tert-butyl (1RS,6SR)-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester
CAS: 161157-50-2
Molecular Formula: C10H17NO3
tert-butyl (1RS,6SR)-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate - Names and Identifiers
tert-butyl (1RS,6SR)-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate - Physico-chemical Properties
| Molecular Formula | C10H17NO3 |
| Molar Mass | 199.25 |
| Density | 1.141±0.06 g/cm3(Predicted) |
| Boling Point | 272.5±23.0 °C(Predicted) |
| Appearance | clear liquid |
| Color | Colorless to Light orange to Yellow |
| pKa | -0.83±0.20(Predicted) |
| Storage Condition | Keep in dark place,Sealed in dry,Room Temperature |
tert-butyl (1RS,6SR)-7-oxa-3-aza-bicyclo[4.1.0]heptane-3-carboxylate - Introduction
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester is an organic compound with the chemical formula C11H19NO3. It is a white crystalline solid.
Nature:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester is a stable compound with low volatility at room temperature. It has good solubility and can be dissolved in common organic solvents. It has a melting point of about 80-85°C.
Use:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester is widely used in organic synthesis. It can be used as a protective group to protect the amine functional group to prevent unnecessary interference in the chemical reaction. In addition, it can also be used as an intermediate in the synthesis of other biologically active compounds.
Method:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester can be prepared by reacting N-Boc-piperidine with an alkylene oxide (such as propylene oxide) under basic conditions. Usually, this reaction is carried out in a suitable solvent, and an appropriate amount of base catalyst is added, and the reaction temperature can be controlled between room temperature and the boiling point of the reactant.
Safety Information:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester has low toxicity under normal operating conditions. However, as an organic compound, it still needs to be operated under safe conditions. At the time of contact, skin contact and inhalation should be avoided, and contact with eyes and mouth should be avoided. If swallowed or mistakenly into the eye, should immediately seek medical attention. During use, maintain good ventilation and wear appropriate personal protective equipment, such as gloves and glasses.
Nature:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester is a stable compound with low volatility at room temperature. It has good solubility and can be dissolved in common organic solvents. It has a melting point of about 80-85°C.
Use:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester is widely used in organic synthesis. It can be used as a protective group to protect the amine functional group to prevent unnecessary interference in the chemical reaction. In addition, it can also be used as an intermediate in the synthesis of other biologically active compounds.
Method:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester can be prepared by reacting N-Boc-piperidine with an alkylene oxide (such as propylene oxide) under basic conditions. Usually, this reaction is carried out in a suitable solvent, and an appropriate amount of base catalyst is added, and the reaction temperature can be controlled between room temperature and the boiling point of the reactant.
Safety Information:
7-Oxa-3-azabicyclo[4.1.0]heptane-3-carboxylic acid, 1,1-dimethylethylester has low toxicity under normal operating conditions. However, as an organic compound, it still needs to be operated under safe conditions. At the time of contact, skin contact and inhalation should be avoided, and contact with eyes and mouth should be avoided. If swallowed or mistakenly into the eye, should immediately seek medical attention. During use, maintain good ventilation and wear appropriate personal protective equipment, such as gloves and glasses.
Last Update：2024-04-10 22:29:15
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CAS: 161157-50-2
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QQ: 3008007409
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CAS: 161157-50-2
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
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